Pseudouridine

$100.00

98%
CAS:
1445-07-4
Molecular Formula: C9H12N2O6
Molecular Weight: 244.20 g/mol
InChI key: PTJWIQPHWPFNBW-GBNDHIKLSA-N
SMILES: O=C1N\C=C(/C(=O)N1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O
PubChem CID: 15047
IUPAC name: 5-(β-D-Ribofuranosyl)pyrimidine-2,4(1H,3H)-dione

Description

Pseudouridine

$100.00

More than 70 years since Cohn and Volkin described several unknown nucleotides, one now known as Pseudouridine[1], the prevalence[2] and significance[3] of Pseudouridine is understood. We are offering a secure onshore supply of Pseudouridine and other analogues[4] to facilitate chemical and biological research* and the manufacture of highly important oligonucleotides for the use of our customers. *This product is intended for Research-Use-Only (RUO).

[1] Cohn, W., Volkin, E. Nucleoside-5′-Phosphates from Ribonucleic Acid. Nature. 1951, 195 167, 483–484. https://doi.org/10.1038/167483a0.

[2] Penzo, M., Guerrieri, A. N., Zacchini, F., Treré, D., Montanaro, L. RNA Pseudouridylation in Physiology and Medicine: For Better and for Worse. Genes (Basel). 2017, Nov 1;8(11):301. doi: 10.3390/genes8110301.

[3] Morais P., Adachi H., Yu Y. T. The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines. Front Cell Dev Biol. 2021, Nov 4;9:789427. doi: 10.3389/fcell.2021.789427.

[4] Link to general BPL page of natural and modified nucleotides